Document 0450
 DOCN  M9480450
 TI    Anaemia, blood transfusion practices, HIV and mortality among women of
       reproductive age in western Kenya.
 DT    9410
 AU    Zucker JR; Lackritz EM; Ruebush TK; Hightower AW; Adungosi JE; Were JB;
       Campbell CC; Malaria Branch, Centers for Disease Control and
       Prevention,; Public Health Service, US Department of Health and Human;
       Services, Atlanta, GA 30333.
 SO    Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):173-6. Unique Identifier :
       AIDSLINE MED/94310625
 AB    Severe anaemia among women in sub-Saharan Africa is frequently treated
       with blood transfusions. The risk of transmission of human
       immunodeficiency virus (HIV) through blood products has led to a
       re-evaluation of the indications for transfusions. Prospective
       surveillance of women admitted to a district hospital in western Kenya
       was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb)
       transfusion status, and outcome. Of the 2986 enrolled women (mean Hb
       10.4 g/dL, SD +/- 2.6, median age 24.4 years), 6% were severely anaemic
       (Hb < 6.0 g/dL). Severe anaemia was associated with a higher mortality
       rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval
       (CI) 2.6, 34.2) compared with women with Hb > or = 6.0 g/dL. Decreased
       mortality rates in hospital were observed with increasing Hb values (OR
       = 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve
       survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable
       mortality due to HIV infection and severe anaemia was 75% and 31%,
       respectively. Maternal/child health care services must include
       prevention strategies for HIV transmission and the prevention,
       recognition, and treatment of severe anaemia.
 DE    Adolescence  Adult  Anemia/BLOOD/*MORTALITY/THERAPY  *Blood
       Transfusion/STATISTICS & NUMER DATA  Female  Hemoglobins/ANALYSIS
       Hospital Mortality  Hospitalization  Human  HIV
       Infections/BLOOD/*MORTALITY/TRANSMISSION  Kenya/EPIDEMIOLOGY  Logistic
       Models  Multivariate Analysis  Pregnancy  Pregnancy Complications,
       Hematologic/BLOOD/MORTALITY  Prospective Studies  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).